- 作者: 王惠珀 ; 李昂 ; 范進財 等
- 作者服務機構: 台灣大學藥學系
- 中文摘要: A new synthesis of antihyperlipoproteinemic agent 2,2- dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid (gemfibrozil) is developed via hydrogenolysis of a novel .beta.-lactone, prepared from [ 2+2 ] cycloaddition of 3-(2,5- dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.
- 英文摘要: --
- 中文關鍵字: Antihyperlipoproteinemic Agent; Synthesis; [ 2+2 ] Cycloaddition; Dimethylketene
- 英文關鍵字: 抗脂蛋白血過多藥;合成;[2+2]環加成;二甲基乙烯酮