- 作者: 黃德彥; 陳興順; 古振濤
- 作者服務機構: Department of Chemistry, Tamkang College of Arts and Sciences, Tamsui, Taiwan 251
- 中文摘要: 12-Methl-1,2,3,4,6,7,12,12b-octahydroindolo[2, 3-a] quinolizine (1) is synthesized through a new route developed in our laboratory. The most important step in this synthesis is the condensation of l-methyltryptophyl bromide (4) with 2-piperidone (5) to give N-[2-(l-methylidol)-3-ylethyl]-2-piperidone (6) in good yield (70%). The synthesis of l-benzoyl-1,2,3,4,6,7,12,12b-octahydroindolo[2, 3-a]quinolizine (2) and l-phenylcarbinol-1,2,3,4,6,7,12, 12b-octahydroindolo[2,3-a]quinolizine (3) follow the method developed by Wenkert. But the yield of tetrahydropyridine 9 from partial hydrogenation of pyridinum bromide 8 with 10% palladium-charcola is 84% which is much higher than the best yield (40%) in the literature, since the phenyl group contribute additional stability.
- 英文摘要: --
- 中文關鍵字: --
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