- 作者: 林山陽 ; 高聿虹
- 作者服務機構: Dept. of Medical Research, Veterans General Hospital, VACRS, R.O.C.
- 中文摘要: The effects of grinding and the excipients used on the solid state stability of warfarin in ground mixtures with.beta.-cyclodextrin or microcrystalline cellulose have been investigated by using x-ray powder diffractometry, IR spectrophotometry and differential scanning calorimetry. The grinding process did not result in warfarin-excipient interaction, but caused a crystalline form of warfarin to transfer to an amorphous state in the presence of .beta.- cyclodextrin. The stability of this amorphous state of warfarin in tablets made from the ground mixtures stored at 37.degree.C and 75% RH (relative humidity) was also studied. There was only a small amount of amorphous warfarin in tablets that recrystallized under storage conditions. The recrystallization of amorphous warfarin might be due to moisture adsorption. .beta.-Cyclodextrin possesses an ability to prevent the recrystallization of large amounts of amorphous warfarin in tablets stored at 37.degree.C and 75% RH.
- 英文摘要: --
- 中文關鍵字: Warfarin; .Beta.-Cyclodextrin; Grinding; Inclusion Complex; Stability
- 英文關鍵字: 殺鼠靈;.beta.-環糊精;研磨;包含複合物;穩定性