- 作者: Hsiao-Kuey Chang; Robert C. Gallo; Barbara Ensoli
- 作者服務機構: Laboratory of Tumor Cell Biology, National; Cancer Institute, National Institutes of; Health, Bethesda, Md., USA
- 中文摘要: --
- 英文摘要: The human immunodeficiency virus type 1 Tat protein is a potent activator of viral gene expression and replication. Tat can also affect the expression of cellular genes including cytokines, extracellular matrix proteins, enzymes degrading the basement membrane and cell cycle-related proteins, and can regulate cellular functions such as growth, migration and angiogenesis. In addition, under certain circumstances, Tat may have tumorigenic effects. These activities of Tat appear to be mediated by different mechanisms such as the transactivation of cellular gene expression or the interaction of extracellu- lar Tat with the cell membrane through both receptor-mediated and non- receptor-mediated interactions. Deregulation of cellular gene expression and function by Tat cause abnormalities which may participate in AIDS pathogen- esis and in the development of AIDS-associated disorders.
- 中文關鍵字: --
- 英文關鍵字: HIV-1; Tat; Transactivation; Cytokine genes; Extracellular matrix proteins; Cell growth; Angiogenesis; Tumorigenesis