- 作者: 李志雄 ; 陳秀和
- 作者服務機構: 中山大學化學系
- 中文摘要: Enantiomers of .beta.-lactams bearing aryl, furyl or styryl substituents in the 4-position were chromatographically separated by means of high-performance liquid chromatography on chiral column packed with amino acid-derived chiral stationary phase. Separation factors are generally modest. To improve further the resolution of enantiomers, the rings of these .beta.-lactams were opened with octanol in acidic conditions and converted into N-3,5- dinitrobenzoyl ester derivatives of the resulting . beta.- amino acids. Enantiomers of these derivatives are efficiently separated on an amide-derived chiral stationary phase. The chromatographic separations enable accurate determination of optical purity of the chiral .beta.- lactams, prepared from homochiral ester enolate-imine condensation. The absolute configuration of the major enantiomer of the .beta.-amino acid derivatives was determined from elution order on a chiral column.
- 英文摘要: --
- 中文關鍵字: Lactam; High-Performance Liquid Chromatography; Chiral Stationary Phase; Enantiomeric Purity; Absolute Configuration
- 英文關鍵字: 內醯胺;高效能液相層析法;對掌靜止相;鏡像異構純度;絕對組態