- 作者: 連金城, 蔣宇東, 陳俊仁, 郭盛助, 黃麗嬌
- 作者服務機構: Graduate Institute of Pharmaceutical Chemistry, China Medical University, 91 Hsueh-Shin Road, Taichung, Taiwan, R.O.C
- 中文摘要: In continuing search for novel cell differentiation agents, a series of derivatives of indole-3-acetic acid and indole-3-carboxylic acid were prepared and tested against HL-60 cells for their differentiation and antiproliferation activities. Among them, N-ethyl-1-benzylindole-3-carboxamide (14) was the most potent, whereas N-methyl 1-benzylindole-3-acetamide (5) and N-methyl 1-benzylindole-3-carboxamide (13) synergistically potentiated with all-trans-retinoic acid to induce cell differentiation as well as antiproliferation. Our results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid.
- 英文摘要: --
- 中文關鍵字: Cell differentiation; Antiproliferation activity; Indole-3-acetic acids; Indole-3-carboxylic acids.
- 英文關鍵字: --