- 作者: Chi-Feng Liu a, Mei-Hsiu Lin b, Chun-Ching Lin e, Hui-Wen Chang d, Song-Chow Lin c
- 作者服務機構: a National Taipei College of Nursing, b Medical Research Institute, c Department of Pharmacology, Taipei Medical University, d Department of Experimental Diagnosis, Taipei Medical University Hospital, Taipei, e Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Acute administration of absolute ethanol (10 ml/kg) peros to fasted mice produced extensive renal failure asmeasured by arise in blood urea nitrogen and creatinine.Pretreatment with oral administration of tetramethylpy-razine (TMP) prevented such failure. The maximal effectagainst absolute ethanol-induced renal failure could beobserved 1 h after TMP administration. In order to furtherinvestigate the renal protective mechanism of TMP, ex-periments on lipid peroxidation and superoxide scav-enging activity were conducted. Renal homogenatesmade from mice treated with ethanol showed that TMPpretreatment had an antioxidant effect. Mice in acuterenal failure had higher malonic dialdehyde concentra-tions than those pretreated with TMP. The renal protec-tive mechanism of TMP was attributed, in part, to itsprominent superoxide scavenging effect, which protectsthe kidney from superoxide-induced renal damage.
- 中文關鍵字: --
- 英文關鍵字: Antioxidant, Absolute ethanol, Tetramethylpyrazine, Lipid peroxidation, Malonic dialdehyde, Cytochrome C