- 作者: Schultz, Arthur G.
- 作者服務機構: Dept. of Chemistry, Rensselaer Polytechnic Inst., Troy, New York, U.S.A.
- 中文摘要: Methods for the enantioselective synthesis of chiral cyclohexane derivatives from aromatic carboxylic acids are presented. Birch reduction-alkylation of chiral benzamides of type 1 occur with high diastereose-lectivities to give 1,4-cyclohexadiene derivatives with quaternary centers located at C(6). Early applications of this chemistry provided target structures with a quaternary center derived from C(1) of the starting benzoic acid derivative. Herein are described (1) the development of a more versatile Birch reduction-alkylation, (2) a practical "asymmetric linkage" between aromatic carboxylic acids and chiral cyclic structures, and (3) asymmetric syntheses of unnatural alkaloids; applications to opiate receptor pharmacology.
- 英文摘要: --
- 中文關鍵字: Enantioselective Synthesis; Birch Reduction-Alkylation; Asymmetric Linkage; Opiate Receptor; Asymmetric Synthesis
- 英文關鍵字: 對映選擇性合成;Birch還原烷化;非對稱連接;麻醉性接受體;非對稱合成