• 作者： 曹之憲; 韓偉
• 作者服務機構： 榮民總醫院醫學研究部; 國立陽明醫學院神經科學研究所
• 中文摘要： 我們研究了木瓜酵素對大白鼠胃酸分泌之作用，發現了下列各點：1．餵食由生木瓜皮收取之乳白汁液（500mg/kg Latex）可減低由Methacholine引起之冑酸分泌。2．餵食純木瓜酵素（3.2mg/kg）可減低由histamine，methacholine及tetragastrin引起之胃酸分泌。3。此木瓜酵素之作用，自餵食後二小時出現，延續48小時之久，至96小時時，作用已消失。4.腹腔注射木瓜酵素對胃酸分泌無影響。這些結果顯示，木瓜酵素是局部作用於胃粘膜而降低胃酸之分泌，其作用是可逆的，在單一劑量之授與情況下，不致造成胃粘膜之永久性損害。
• 英文摘要： We studied the effect of papain on rats' gastric acid secretion and found that: 1. Feeding of latex ofunripe papaya fruit significantly reduced gastric acid secretion induced by methacholine; 2. Feeding ofcrystalline papain in doses of 3.2 mg/kg reduced gastric acid secretion induced by histamine, methacholineand tetragastrin; 3. The reduction of gastric acid secretion was observed as early as 2 hours after papainfeeding, lasted up to 48 hours, and waned within 96 hours; 4. Intraperitoneal injection of papain had noeffect on acid secretion. These results led us to believe that the effect of papain on gastric acid secretionis a local one acting directly on the gastric mucosa, and this local effect of a single dose of papain is re-versible, causing no permanent damage to the mucosa.
• 中文關鍵字： papain; gastric; sercretion; secretagogues
• 英文關鍵字： --