- 作者: 林家立 ; 劉曉倩 ; 吳芳禎 等
- 作者服務機構: 中興大學化學系
- 中文摘要: Aryl .alpha.,.alpha.-difluoroalkyl ketones were synthesized from the reaction of ethyl .alpha.,.alpha.- difluoroacylate with aryl lithium at -78.degree.C or from the coupling of aryl iododifluoromethyl ketone with 1- alkene in the presence of teterakis(triphenylphosphine) palladium(0). These compounds were potent inhibitors of pancreatic cholesterol esterase with K/sub i/ values in the range 15.mu.M to 20nM.
- 英文摘要: --
- 中文關鍵字: Aryl Difluoroalkyl Ketone; Inhibitor; Cholesterol Esterase; Inhibition Constant
- 英文關鍵字: 芳基二氟烷基酮;抑制劑;膽固醇酯化;抑制常數