- 作者: Gang Wu, Xupei Huang, Yimin Hua and Dezhi Mu
- 作者服務機構: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, Mainland China
- 中文摘要: --
- 英文摘要:
Neural tube defects (NTDs) are the second most common birth defect in humans.
Despite many advances in the understanding of NTDs and the identification of many
genes related to NTDs, the fundamental etiology for the majority of cases of NTDs
remains unclear. Planar cell polarity (PCP) signaling pathway, which is important for
polarized cell movement (such as cell migration) and organ morphogenesis through
the activation of cytoskeletal pathways, has been shown to play multiple roles during
neural tube closure. The disrupted function of PCP pathway is connected with some
NTDs. Here, we summarize our current understanding of how PCP factors affect the
pathogenesis of NTDs. - 中文關鍵字: --
- 英文關鍵字: Neural tube defects, planar cell polarity, organ morphogenesis, signaling pathway