- 作者: Pao-Pao Yang; Eagle Yi-Kung Huang; Geng-Chang Yeh; Pao-Luh Tao
- 作者服務機構: 1 Department of Pharmacology, National Defense Medical Center, P.O. Box 90048-504, Nei-Hu 114, Taipei, Taiwan, R.O.C; ; 2 Department of Pediatrics, Taipei Medical University Hospital. Taipei Medical University, Taipei, Taiwan, R.O.C
- 中文摘要: --
- 英文摘要: Methamphetamine (MA) is well known as a potent CNS stimulant, which produces strong rewarding and behavioral sensitization after repeated administration. In the present study, we investigated whether coadministration of dextromethorphan (DM) with MA could suppress these effects induced by acute and chronic MA treatment. The conditioned place preference (CPP) test was used to examine the rewarding/ drug seeking effects and locomotor and stereotypic activities were measured to investigate behavioral sensitization induced by chronic MA. Our results revealed that co-administration of DM (20 mg/kg, ip) with MA (2 mg/kg, ip) almost completely abolished the MA-induced CPP and behavioral sensitization. Furthermore, both of the acute and chronic MA could result in an increase of dopamine (DA) turnover rate in the NAc and mPFC. The acute effects of MA on DA turnover rate could be attenuated by the coadministration of DM in both regions. The chronic effect of MA on DA turnover rate in the mPFC was also attenuated by the co-administration of DM. These results suggest that the effect of DM on blocking MA-induced rewarding and behavioral sensitization may be related to its effect on inhibiting the activity of DA neurons projected to mPFC and/or NAc
- 中文關鍵字: --
- 英文關鍵字: behavioral sensitization, dextromethorphan, dopamine, methamphetamine, nucleus accum-bens, rewarding, ventral tegmental area