- 作者: Hui-Yun Chang, Tzu-Kang Sang and Ann-Shyn Chiang
- 作者服務機構: 1. Department of Medical Science, Institute of Systems Neuroscience, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, R.O.C. 2. Department of Life Science, Institute of Biotechnology, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, R.O.C.
- 中文摘要:
- 英文摘要:
Abstract
Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including Alzheimer’s disease (AD), and various Parkinsonism. Tau protein undergoes a plethora of intra-molecular modifications and some altered forms promote the production of toxic oligomeric tau and paired helical filaments, and through which further assemble into neurofibrillary tangles, also known as tauopathy. In this review, we will discuss the recent advances of the tauopathy research, primarily focusing on its association with the early axonal manifestation of axonal transport defect, axonal mitochondrial stress, autophagic vesicle accumulation and the proceeding of axon destruction, and the pathogenic Tau spreading across the synapse. Two alternative strategies either by targeting tau protein itself or by improving the age-related physiological decline are currently racing to find the hopeful treatment for tauopathy. Undoubtedly, more studies are needed to combat this devastating condition that has already affected millions of people in our aging population. - 中文關鍵字:
- 英文關鍵字: Microtubule associated protein tau, Brain connectome, Tauopathy, Alzheimer’s disease, Parkinson’s disease, Proteinopahty, trans-synaptic spreading, Mitochondria, age-dependent neurodegenerative diseases