- 作者: 李協融,陳行明,陳伯淵,蔡瑞琪,陳亮宇,王英基*,黃怡婷,魏筠蓁,呂佩融*
- 作者服務機構: Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.Institute of Clinical Medicine, National Cheng Kung University,
- 中文摘要:
The synthesis of neoflavene and neoflavenes with methoxy substituents at different positions are described.
As starting materials, various salicylaldehydes were run through sequential reactions such as
O-allylation, Grignard reaction, oxidation,Wittig reaction, and ring-closing metathesis to yield the target
neoflavenes in good yield. Among the prepared neoflavenes, 7-methoxy-4’-methoxyneoflavene (6e) and
methoxy-4’-methoxyneoflavene (6f) exhibiting potential cell toxicities against various cells were disclosed.
In particular, 6f which exhibited an IC50 value of 6.5±2.0 and 5.1±1.1μM against gastric carcinoma
and lung carcinoma cells in vitro was found, respectively.Meanwhile, the structure and activity relationship
of our synthesized neoflavenes is further discussed briefly. - 英文摘要: --
- 中文關鍵字: Neoflavenes; Ring-closing metathesis; Cytotoxicities.
- 英文關鍵字: --