- 作者: Jennifer HUI-CHUN Ho; Chuang-Ye Hong
- 作者服務機構: Graduate Institute of Clinical Medicine, Taipei Medical University, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Salvianolic acids are the most abundant water-soluble compounds extracted from
Radix Salvia miltiorrhiza (Danshen). In China, Danshen has been wildly used to treat
cardiovascular diseases for hundreds of years. Salvianolic acids, especially salvianolic
acid A (Sal A) and salvianolic acid B (Sal B), have been found to have potent
anti-oxidative capabilities due to their polyphenolic structure. Recently, intracellular
signaling pathways regulated by salvianolic acids in vascular endothelial cells, aortic
smooth muscle cells, as well as cardiomyocytes, have been investigated both in vitro
and in vivo upon various cardiovascular insults. It is discovered that the
cardiovascular protection of salvianolic acids is not only because salvianolic acids act
as reactive oxygen species scavengers, but also due to the reduction of
leukocyte-endothelial adherence, inhibition of inflammation and metalloproteinases
expression from aortic smooth muscle cells, and indirect regulation of immune
function. Competitive binding of salvianolic acids to target proteins to interrupt
protein-protein interactions has also been found to be a mechanism of cardiovascular
protection by salvianolic acids. In this article, we review a variety of studies focusing
on the above mentioned mechanisms. Besides, the target proteins of salvianolic acids
are also described. These results of recent advances have shed new light to the
development of novel therapeutic strategies for salvianolic acids to treat
cardiovascular diseases. - 中文關鍵字: --
- 英文關鍵字: --