• 作者： 范秉真; 趙大衛; 劉和榮; 李金木; 鄭峰鶯; 王錦惠; 吳惠城
• 作者服務機構： 國立陽明醫學院醫學及榮民總醫院醫學研究部寄生蟲學研究室
• 中文摘要： 本項研究於68年6月I日～69年5月1日在宜蘭縣南澳鄉、壯圍鄉及屏東縣滿州鄉二所國民中學及十三所國民小學先後完成學童寄生蟲之調查及治療。現將所得結果簡介於后：(一)寄生蟲病之流行 (1)頭蝨之傳染率：利用肉眼觀察及梳刷法，檢查女生 2,509 人，頭蝨平均傳染率為40%。 (2)蟯蟲之傳染率：利用玻璃膠紙肛圍擦拭法，僅檢查一次，檢查學童 2,264 人，平均傳染率為29%。 (3)常見腸道寄生蟲之傳染率：利用福爾馬林乙醚濃縮法，試管濾紙培養法及玻璃膠紙肛圍擦
• 英文摘要： The present study was performed from June1, 1978 to May 31, 1979. Its purpose is fordetermination of the minimum effective dose ofmebendazole and combantrin in treatment ofcommon intestinal nematode parasites amongschool children in two junior high and 13primary schools in Nan-Ao and Chuang-WeiDistricts of I-Lan County and Man-Chow Districtof Ping-Tung County. The results obtained aresummarized as follows:1. Prevalence of common parasitic diseases: a. Incidence of Pediculus humanus capitis:2,509 girl students were examined by the nakedeye and combing technique, 998 girls were foundto be infected, giving the infection rate of 40%. b. Incidence of Enterobriasis: 2,267 childrenwere examined by single scoth tape anal swab,648 were found infected, giving the infectionrate of 69%. c. Incidence of common intestinal parasiticdiseases: 2,267 stool samples were examined byformalin-ether concentration, test-tubefilter-papercultivation and scotch tape anal swab techniques.The infection rate of 51%, 36%, 30%, 1.1%and 0.2% was found for Trichuris, Ascaris,hookworm, Taenia taiwanensis, and H. nanarespectively.2. Chemotherapy of common intestinal nematode parasites: Mebendazole and combantrin were used intreatment of enterobiasis, ascariasis, hookworminfection and trichuriasis. No fasting and purga-tion before and/or after administration wereneeded. The evaluation of efficacy of“meben-dazole or combantrin”will be assessed thecure rate reaching 90% or over. The minimumeffective dose of 10, 75, 75 and 300 mg ofmebendazole was determined for oxyuriasis,ascariasis, hookworm infection and trichuri-asis respectivity. The corresponding figure of200, 400 and 200 mg of combantrin werealso determined for oxyuriasis, ascariasis andhookworm infection respectively, but no moreeffect was found for trichuriasis. No side-effect was noted in all treated casesexcept mild abdomenal discomfort was revealedin a few cases after treatment with combantrin.Comparatively, both mebendazole and combantrinare highly effective in the treat ment of commonintestinal nematode parasites, but the former ismore effective and safe drug than the latter.Therefore, mebendazole is the most promisinganthelmintic for treatment of common intestinalparasites.
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