- 作者: 蕭明熙
- 作者服務機構: 榮民總醫院醫學研究部
- 中文摘要: Oxygenated lanostanoid triterpenes including multiple pairs of C-3 stereoisomers and C-3/C-15 positional isomers were identified from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst. Empirical rules based on the chromatographic behavior in reversed-phase HPLC were developed to correlate the molecular polarities due to the presence of an individual functional group./sup 13/C NMR correlation of stereochemistry in these oxygenated triterpenes was also achieved. Biosynthetic studies indicated that oxygenated triterpenes in the 3.alpha. series were derived from those in the 3.beta. series through an oxidation-reduction pathway. Several oxygenated triterpenes inhibited cholesterol synthesis in the in vitro assay. Ganodermic acid S induced platelet aggregation by stimulating the hydrolysis of phosphatidylinositol 4,5-bisphosphate.
- 英文摘要: --
- 中文關鍵字: Triterpene; /Sup 13/C Nmr (Nuclear Magnetic Resonance); High Performance Liquid Chromatography (Hplc); Biosynthesis; Platelet Aggregation; Ganoderma Lucidum
- 英文關鍵字: 三烯類;碳十三核磁共振儀;高效能液相層析法;生物合成;血小板凝集;靈芝