- 作者: Pei-Jane Tsai, Yi-Hsin Lai, Rajesh Kumar Manne, Yau-Sheng Tsai, Dos Sarbassov & Hui-Kuan Lin
- 作者服務機構: 1.Biology Department, School of Sciences and Humanities, and National Laboratory Astana, Nazarbayev University, Nur-Sultan City, 010000, Kazakhstan 2.Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA 3.Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 4.Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan 5.Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- 中文摘要:
- 英文摘要:
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senes‑
cence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a central player
transmitting extracellular clues to various cellular compartments, in turn executing these biological processes. Since
the discovery of Akt three decades ago, the tremendous progress towards identifying its upstream regulators and
downstream efectors and its roles in cancer has been made, ofering novel paradigms and therapeutic strategies for
targeting human diseases and cancers with deregulated Akt activation. Unraveling the molecular mechanisms for Akt
signaling networks paves the way for developing selective inhibitors targeting Akt and its signaling regulation for the
management of human diseases including cancer - 中文關鍵字:
- 英文關鍵字: PI3K, Akt, TRAF6, Skp2, Cancer, Posttranslational modifcations