- 作者: Ching-Yuh Cherna, Yung Lee Yekb, Ja-Ding Jana and Wai Ming Kanc
- 作者服務機構: Department of Applied Chemistry, Chao Yang University of Technology, Taichung, Taiwan, R.O.C.
- 中文摘要: Preparation of the enantiomeric pair of 3-[2-(3-benzenesulfonylamino-7-oxabicyclo[2.2.1]hept-2-yl-methyl)phenyl]propionic acid, a novel thromboxane antagonist is reported. They are synthesized from either enantiomers of known (1R,2R,3R,4S)-3-[2-(3-carboxy-7-oxabicyclo[2,2,1]hept-2-yl-methyl)phenyl]- propionic acid methyl ester via epimerization, modified Curtius’ rearrangement and sulfonylamino formation. Other derivatives may be prepared similarly.
- 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --