- 作者: Alsehaibani, Hamad A. ; Abu-Gharib, Ezz-Eldin A.
- 作者服務機構: College of Technology, Riyadh, Saudi Arabia
- 中文摘要:
Solubilities are reported for psoralen and 8- hydroxypsoralen in binary aqueous mixtures at ambient pressure and 298K, with organic cosolvent methanol. Gibb's energies of transfer of these two compounds are calculated from their solubilities. Transfer chemical potentials of both compounds are stabilized by increasing proportion of organic cosolvent because of their markedly hydrophobic character.
Basic hydrolysis of psoralen and 8-hydroxypsoralen in aqueous methanol mixtures was examined kinetically, yielding Gibb's energies of activation. Derived transfer parameters are used in analysis of kinetic data to describe the influence of solvent composition on initial and transition states. Derived transfer chemical potentials for a single ion such as hydroxide ion lead to an interesting comparison of the effects of extrathermodynamic assumptions, Wells estimates and TATB assumption, on the initial and transition states. The analysis confirm the important role played by the choice of extrathermodynamic assumption in determining the overall kinetic pattern. We describe misgivings concerning procedures used by Wells to derive transfer chemical potential for single ions. - 英文摘要: --
- 中文關鍵字: Solubility; Reactivity; Gibb's Energy; Free Energy; Chemical Potential Transfer; Basic Hydrolysis Kinetics
- 英文關鍵字: 溶解度;反應性;自由能;化學位能轉移;鹼水解動力學