- 作者: Rahul Sharma; Sun-sang Joe Sung; Shu Man Fu; Shyr-Te Ju
- 作者服務機構: Center for Immunity, Inflammation, and Regenerative Medicine, and Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
- 中文摘要: --
- 英文摘要:
Scurfy mice display the most severe form of multi-organ inflammation due to total lack
of the CD4+Foxp3+ regulatory T cells (Treg) resulted from a mutation of the X-linked
transcription factor Foxp3. A large repertoire of Treg-suppressible, inflammationinducing
T cells was demonstrated by adoptive transfer experiments using Rag1-/- mice
as recipients and by prolongation of lifespan through breeding with Faslpr/lpr mutant.
Inflammation in the ear, eyes, skin, tail, salivary glands, lungs, stomach, pancreas, liver,
small intestine, colon, skeletal muscle, and accessory reproductive organs are
identified. Genetic and cellular regulations of specific organ inflammation are described.
Sf mice may be useful for the identification of organ-specific antigens and Treg capable
of suppressing inflammation in an organ-specific manner. Sf mice are also useful to
determine the important inflammation process at the checkpoint after Treg regulation
using genetic analysis through breeding. - 中文關鍵字: --
- 英文關鍵字: --