- 作者: 王雲銘 ; 鄭粲煌 ; 許瑞昇 等
- 作者服務機構: 高雄醫學院化學系
- 中文摘要: The new bis(amide) derivatives of DTPA(diethylenetriamine-N,N,N',N",N"-pentaacetic acid), diethyle-netriamine-N,N',N"-triacetic-N,N"-bis(benzylamide)(DTPA-BBA) have been synthesized. The crystal structure of gadolinium(III) complex of DTPA-BBA ( [ Gd (DTPA-BBA) ] ) has been determined by X-ray crystallography: C/sub 28/H/sub 52/ GdN/sub 5/O/sub 17/, M/sub w/=889g mol/sup -1/, space group P.1bar. (#2) (triclinic), a=12.645(4), b=14.125(8), c=12.623(4).ANG., .alpha.=111.60(3), .beta.=114.79(3),. gamma.=88.39(4).degree., V=1881(1).ANG./sup 3/, Z=2, D/sub x/=1.569g/cm/sup 3/, .lambda.(Mo K.alpha.)=0.71069.ANG., .mu.=18.44cm/sup -1/, final R=0.047, R/sub w/=0.046 for 3755 independent observed reflections at 23.degree.C. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water. The relaxivity of Gd(III) complex was determined to be R1=4.08(4) and R2=6.06(5) dm/sup 3/mmol/sup -1/s/sup -1/ at pH=7.0, 20MHz, and 37(1). degree.C. Additionally, the R1 relaxivity for Gd(III) chelate was found to be invariant with respect to pH changes over the range of 2-10. This indicates that a constant inner-sphere hydration number is associated with the [ Gd(DTPA-BBA) ] complex. Hence the high stability of the complex is demonstrated.
- 英文摘要: --
- 中文關鍵字: Crystal Structure; Gadolinium Complex; Relaxivity; Magnetic Resonance Imaging Contrast Agent
- 英文關鍵字: 晶體結構;釓錯合物;遲緩率;磁振造影對比劑