- 作者: Yongzheng Wang; Xuwei Hou; Yuliang Li
- 作者服務機構: Department of Interventional Radiology, The Second Hospital of Shandong University, Shangdong, China
- 中文摘要: --
- 英文摘要:
Background: The association of TGF β1 polymorphisms and atrial fibrillation (AF) in
essential hypertensive (EH) subjects remains unknown.
Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled.
The polymorphisms of +869 T→C at codon 10 and + 915 G→C at codon 25, were
genotyped. The clinical characteristics including serum TGF β1 levels were detected.
Results: The GG genotypes of TGF β1 +915 G→C at codon 25 were more prevalent
in subjects from EH+AF+ group than those from EH+AF- group (P=0.009). The
subjects with GG genotype from EH+AF+ group had the highest mean serum TGF β1
level, which was significantly higher than that of GG genotype subjects from EH+AFgroup
(3.18±0.24 ng/dl vs.2.29±0.14 ng/dl, P<0.05). Multiple analyses revealed that
the TGF β1 GG genotype of +915 G→C at codon 25 presented a 3.09 times higher
risk in developing AF in the multivariate model after adjusting for age and gender.
Conclusion: The polymorphisms of TGF β1 +915 G→C at codon 25 were associated
with occurrence of AF and serum TGF β1 level in EH subjects. - 中文關鍵字: --
- 英文關鍵字: --