• 作者： 段筠心; 吳慶明; 沈清良
• 作者服務機構： 國立成功大學醫學院解剖學科
• 中文摘要： 本實驗是以免疫組織化學方法來研究Serotonin（5-HT）在不同種動物之中樞神經系統中的分佈。研究結果發現在倉鼠、天竺鼠、兔及大白鼠的腦幹中，含Serotonin的神經元主要集中在中線縫核群、尤其是蒼白縫核、不明縫核、巨細胞縫核、中央縫核、橋腦縫核及背側縫核等。這些含Serotonin的細胞體之分佈常呈帶狀或翼狀，並且由縫核區向兩側延伸入網狀結構內，與Catecholamine（兒茶酚胺）系統混合。此二系統混合之分佈情形在兔和倉鼠的腦幹中尤其明顯，其腦幹中Serotonin的細胞體之分佈較大白鼠及天竺鼠的為寬，且向側面延伸得更廣。另外在延腦的網狀副巨細胞核上亦發現含Serotonin的神經元。以上5-HT神經元的廣泛分佈顯示5-HT在神經系統之功能上可能扮演著重要角色。
• 英文摘要： Immunohistochemical techniques were employed to study the distribution of serotonin (5-HT)immunoreactive neurons in the brainstem of the hamster, guinea pig, rabbit and rat. 5-HT neurons wereprincipally found to be concentrated in the midline raphe nuclei, particularly, the raphe pallidus, rapheobscurus, raphe magnus, raphe median, raphe pontis and raphe dorsalis nuclei. Characteristically, thesecell bodies are displayed in bands or wing-like patterns which extend laterally from the raphe into reticularformations. The formations often appear to blend with the catecholamine system. They are particularlyevident in the brainstems of the rabbit and hamster which contain wider and more lateral extensions of theserotonergic (5-HT) neurons than those observed in the brainstems of the rat and guinea pig. The wide-spread distribution of 5-HT immunoreacted cell bodies in the brainstem shows that there are significantprospects of 5-HT in neuronal activities.
• 中文關鍵字： serotonin; neuron; serotonin immunoreactive; brainstem
• 英文關鍵字： --