• 作者： 林文翰; 林碧堯; 陳明德; 鄭葳; 鄒中泰; 王玉潯; 林燄
• 作者服務機構： 榮民總侯院臺中分院內科部; 小兒科; 私立東海大學化學系; 私立東海大學生物研究所
• 中文摘要： 鋅之代謝作用及其對甲狀腺素轉換作用，在肥胖能量產生情形的控制與調節作用上，可能具重要的影響，以動物實驗，每隻營養誘發性肥胖小鼠，每日給予1.25毫克硫酸鋅與（或）5微克甲狀腺素，經8週後，以斷頭法抽取小鼠血樣，測定血清鋅與三脂醯甘油酯的含量及測定小鼠體脂肪含量。本實驗發現，鋅在肥胖小鼠的能量代謝上，具有特殊的調節作用。在餵食高脂飼料之雄性小鼠，當給予硫酸鋅，其體脂肪堆積較為明顯。然而給予甲狀腺素時，小鼠的體脂肪顯著下降，但三脂醯甘油酯並無顯著變化。當同時給予硫酸鋅及甲狀腺素時，小鼠體脂肪顯著下降，且對三脂醯甘油酯含量有意義的改變。鋅與甲狀腺素間，在不同的飼料脂肪比例下，對於能量代謝調節上，會造成不同的結果。肥胖的發生與食物脂肪含量，鋅及甲狀腺素間可能具有重要關係，由最近之發現可推論，鋅與甲狀腺素的轉換作用及與胰島素作用之間的調節方式與機轉，可能對肥胖小鼠的能量代謝具重要的關係。
• 英文摘要： Altered thyroid hormone metabolism is known to be an important factor contributing to the defec-tive expression of thermogenesis in the obese mouse, and the action of zinc on thyroid hormone con-version may be an important factor in the energy metabolism of obesity. The effects of zinc and thyroxinetreatment on dietary-obese mice were examined. The dietary-obese mice were successfully induced byhigh-fat diet (80% fat), and every mouse was administered daily 1.25 mg zinc sulfate and/or 5 μg thyroxine.After 8 weeks of treatment, serum zinc, serum triacylglycerols and body fat composition were determined.On high-fat diets, fat deposition was found in male mice treated with zinc sulfate. However, when micewere treated with zinc and thyroxine at the same time, serum triacylglycerols and body fat compositiondecreased significantly on both basal and high-fat diets. When mice were treated with thyroxine alone,body fat composition decreased signficantly, but there was no significant effect on serum triacylglycerolson either diet. Obesity was significantly correlated with dietary fat, zinc and thyroid hormone. It is sug-gested that zinc may play an important role, through Rs action on thyroid hormone conversion and viainsulin action, in the energy metabolism of dietary-obese mice.
• 中文關鍵字： dietary-obese mice; zinc; thyroxine; body fat composition; thyroid hormone conversion
• 英文關鍵字： --