• 作者： 謝明村; 陳和昌; 高惠珍; ?谷健
• 作者服務機構： 中國醫藥學院中國藥學研究所附設醫院; 日本東京醫科大學藥理學教室
• 中文摘要： 中國古方酸棗仁湯是一種根有效的抗焦慮劑，著者等曾探討其作用機轉，顯示酸棗仁湯能降低中樞單胺之轉換速率及兒茶胺之活性。 本研究結果發現酸棗仁湯（1）能顯著地拮抗由5-HTP所誘發引起之運動量抑制現象。（2）能顯著地抑制由p-CPA所誘發引起之運動量興奮現象。（3）對baclofen，muscimol，AOAA和thiosemicarbazide等所誘發引起運動量之影響，在統計上無顯著的意義。（4）能顯著地降低 VMA在腦部striatum及hippocampus處之濃度，HVA在腦部hippocampus處之濃度及5-HIAA在腦部striatum及hypothalamus處之濃度。（5）腦部striatum及hippocampus處由α-MT所產生DA濃度的降低，酸棗仁湯能顯著地將其反轉。（6）腦部amygdala處由p-CPA所產生5-HT濃度的降低，酸棗仁湯能顯著地將其反轉。 由以上實驗結果顯示，酸棗仁湯能夠影響serotonergic的活性，但對GABAergic的活性並無顯著的影響，且其主要的作用位置可能是在中樞邊綠葉系統。
• 英文摘要： Previously, we found that the ancient Chinese remedy of Suanzaorentang was a promising anxiolyticdrug (Chen and Hsieh, 1985; Chen and Hsieh, 1985a). We also found that Suanzaorentang decreased theturnover rate of central monoamines and central catecholaminergic activity (Hsieh, et al., 1986). In this study, we found that (1) 5-hydroxytryptophan (5-HTP) induced decrease in locomotor acti-vity was significantly antagonized by Suanzaorentang, (2) p-chlorophenylalanine (p-CPA) induced increasein locomotor activity was significantly inhibited by Suanzaorentang, (3) Suanzaorentang had no significanteffects on baclofen, muscimol, aminooxyacetic acid (AOAA) and thiosemicarbazide induced changes inlocomotor activity, (4) Suanzaorentang significantly decreased vanillylmandelic acid (VMA) in striatum andhippocampus, homovanillic acid (HVA) in hippocampus and 5-hydroxyindol acetic acid (5-HIAA) in stria-turn and hypothalamus, (5) Suanzaorentang significantly reversed theα-methyltyrosine (a-MT) produceddecrease in DA concentrations in striatum and hippocampus, and (6) Suanzaorentang significantly reversedthe p-CPA produced decrease in 5-HT concentrations on amygdala. These facts implied that Suanzaoren-tang might decrease the serotonergic activity but have no significant effect on GABAergic activity. Themain locus of action might be in the limbic system.
• 中文關鍵字： Suanzaorentang; adrenergic; serotonergic
• 英文關鍵字： --