• 作者： C W. Chang; F.L. Hsu; J.Y. Lin
• 作者服務機構： a Institute of Biochemistry, College of; Medicine, National Taiwan University, b School of Pharmacy, Taipei Medical; College, Taipei, Taiwan, ROC
• 中文摘要： --
• 英文摘要： Three polyphenolic catechins, epigallocatechin (1), epicatechin-3-O-gallate (2) and epigallocatechin-3-O-gallate (3), were isolated from Chinese green tea, Ti- Kaun-Yin (Camellia sinensis) and demonstrated as a new class of human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor. The con- centrations required for 50% inhibition for the compounds (1), (2) and (3) were 7.80, 0.32 and 0.68μM, respectively. The polyphenolic catechins with a galloyl group at the 3 position were potent inhibitors of HIV-RT. Kinetic anal- ysis indicated that the polyphenolic catechins were competitive inhibitors with respect to the template-primer (rA)n (dT)12-18 and noncompetitive inhibi- tors to dTTP.
• 中文關鍵字： --
• 英文關鍵字： Polyphenolic catechins; HIV reverse transcriptase activity