- 作者: C W. Chang; F.L. Hsu; J.Y. Lin
- 作者服務機構: a Institute of Biochemistry, College of; Medicine, National Taiwan University, b School of Pharmacy, Taipei Medical; College, Taipei, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Three polyphenolic catechins, epigallocatechin (1), epicatechin-3-O-gallate (2) and epigallocatechin-3-O-gallate (3), were isolated from Chinese green tea, Ti- Kaun-Yin (Camellia sinensis) and demonstrated as a new class of human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor. The con- centrations required for 50% inhibition for the compounds (1), (2) and (3) were 7.80, 0.32 and 0.68μM, respectively. The polyphenolic catechins with a galloyl group at the 3 position were potent inhibitors of HIV-RT. Kinetic anal- ysis indicated that the polyphenolic catechins were competitive inhibitors with respect to the template-primer (rA)n (dT)12-18 and noncompetitive inhibi- tors to dTTP.
- 中文關鍵字: --
- 英文關鍵字: Polyphenolic catechins; HIV reverse transcriptase activity