第7卷‧第1期,
197901
, pp. 21-31
5,5二取代苯基丙醯(月尿)之合成
- 作者:
姜宏哲; 黎世源; 施鍚斌
- 作者服務機構:
國立臺灣師範大學化學研究所
- 中文摘要:
二取代苯基丙醯□(diphenyl hydantoin)是一種抗痙攣劑,並為衛生署建議應自製之醫藥品,,本實驗在追試各國文獻及專利之合成法,再加上自行實驗之改良方法,已找出最有效、最經濟之製備方法為採用 Adams & Morvel 改良法,從甲醛製造苯基苯甲醯甲醇(產量90.5%),然後用 Klosa (A)改良法用苯基苯甲醯甲醇製造二取代苯基丙醯□(產量91.7%),如採用試藥級藥品依照上述方法合成,每公斤二取代苯基丙醯□之成本為11.4美元。 採用工業原料級藥品時,從甲醛製造苯基苯甲醯甲醇之產量降為42.1%,從苯基苯甲醯甲醇製造二取代苯基丙醯□之產量為83.5%,總產量為35.2%,合成每公斤二取代苯基丙醯□之成本為7.1美元,比進口價格9.9美元便宜“
- 英文摘要:
The synthetic methods of 5, 5-diphenylhy-dantoin (anticonvlsant drug) were reviewed anddiscussed. For finding an economical method,the proper methods were rechecked and theyield were compared with the reported results.Also the modified methods were developed. The best economical method is developedas follows: 1. Benzaldehyde→benzoin (ModifiedAdams&Morvel method) Yield 90.5%*:42.1%** 2. Benzoin→5, 5-diphenylhydantoin (Mo-dified Klosa (A) method) Yield 91.7%*:83.5%** 3. Cost for one kg 5,5-diphenylhydantoin U. S.$ 11.4 (Total yield 83%)* U. S.$ 7.1 (Total yield 35.2%)** U. S.$ 9.9 (Imported price)
- 中文關鍵字:
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- 英文關鍵字:
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