- 作者: Sang-Soo, Hah
- 作者服務機構: Department of Chemistry and Research Institute for Basic Sciences, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul, Korea.
- 中文摘要: --
- 英文摘要:
The use of radioisotopes has a long history in biomedical science, and the technique of
accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for
detection of very low-abundant, stable and long-lived isotopes, has now revolutionized highsensitivity
isotope detection in biomedical research, because it allows the direct determination of
the amount of isotope in a sample rather than measuring its decay, and thus the quantitative
analysis of the fate of the radiolabeled probes under the given conditions. Since AMS was first
used in the early 90’s for the analysis of biological samples containing enriched 14C for
toxicology and cancer research, the biomedical applications of AMS to date range from in vitro
to in vivo studies, including the studies of 1) toxicant and drug metabolism, 2) neuroscience, 3)
pharmacokinetics, and 4) nutrition and metabolism of endogenous molecules such as vitamins. In
addition, a new drug development concept that relies on the ultrasensitivity of AMS, known as
human microdosing, is being used to obtain early human metabolism information of candidate
drugs. These various aspects of AMS are reviewed and a perspective on future applications of
AMS to biomedical research is provided. - 中文關鍵字: --
- 英文關鍵字: --