- 作者: Felipe P. Perez, Joseph P. Bandeira, Cristina N. Perez Chumbiauca, Debomoy K. Lahiri, Jorge Morisaki & Maher Rizkalla
- 作者服務機構: 1.Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA 2.Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, IN, USA 3.Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA 4.Department of Psychiatry, Institute of Psychiatric Research, Neuroscience Research Center, Indiana University School of Medicine, Indianapolis, IN, USA 5.Division of General Internal Medicine and Geriatrics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA 6.Division of Rheumatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA 7.Indiana University School of Medicine, Indianapolis, IN, USA
- 中文摘要:
- 英文摘要:
We provide a multidimensional sequence of events that describe the electromagnetic feld (EMF) stimulation and
biological system interaction. We describe this process from the quantum to the molecular, cellular, and organismal levels. We hypothesized that the sequence of events of these interactions starts with the oscillatory efect of
the repeated electromagnetic stimulation (REMFS). These oscillations afect the interfacial water of an RNA causing
changes at the quantum and molecular levels that release protons by quantum tunneling. Then protonation of RNA
produces conformational changes that allow it to bind and activate Heat Shock Transcription Factor 1 (HSF1). Activated HSF1 binds to the DNA expressing chaperones that help regulate autophagy and degradation of abnormal
proteins. This action helps to prevent and treat diseases such as Alzheimer’s and Parkinson’s disease (PD) by increasing clearance of pathologic proteins. This framework is based on multiple mathematical models, computer simulations, biophysical experiments, and cellular and animal studies. Results of the literature review and our research point
towards the capacity of REMFS to manipulate various networks altered in aging (Reale et al. PloS one 9, e104973,
2014), including delay of cellular senescence (Perez et al. 2008, Exp Gerontol 43, 307-316) and reduction in levels of
amyloid-β peptides (Aβ) (Perez et al. 2021, Sci Rep 11, 621). Results of these experiments using REMFS at low frequencies can be applied to the treatment of patients with age-related diseases. The use of EMF as a non-invasive therapeutic modality for Alzheimer’s disease, specifcally, holds promise. It is also necessary to consider the complicated
and interconnected genetic and epigenetic efects of the REMFS-biological system’s interaction while avoiding any
possible adverse efects. - 中文關鍵字:
- 英文關鍵字: Repeated electromagnetic feld stimulation, Autophagy, Chaperones, HSF1, Amyloid beta, Alzheimer’s disease, Aging, Age-related disease