- 作者: 郭朝楠 ; 吳明學 ; 陳世平 等
- 作者服務機構: 成功大學化學系
- 中文摘要: .alpha.-Haloformylarylhydrazine hydrohalides (1) were prepared through ring opening of 3-aryl-4-halosydnones with hydrohalic acids in EtOAc in moderate yields. Reactions between compounds (1) and primary alcohols gave alkyl 1- arylhydrazinecarboxylates, important intermediates in syntheses of antiinflammatory drugs. Compounds 4-aryl-2-(arylhydrazin-1-yl)-1,3,4-oxadiazolin-5-ones, and 1,4- diaryl-1,4-dihydro-1,2,4,5-tetrazine-3,6(2H,5H)-diones (18), were synthesized by self -dimerization of compounds (1). Compounds (18) were also converted to compounds 4-arylamino- 1-aryl-1,2,4-triazalidine-3,5-diones via intramolecular rearrangement. Structural elucidation and verification of the reaction mechanisms are presented.
- 英文摘要: --
- 中文關鍵字: Ring Opening Reaction; Sydnone; Intramolecular Rearrangement; Reaction Mechanism; Self-Dimerization
- 英文關鍵字: 開環反應;雪梨酮;分子內重排;反應機構;自我二聚物化