• 作者： Chiu, Hsin-Cheng; Lo, Chun-Liang; Wang, Fu-Ya
• 中文摘要： 在本研究中, 我們利用各種非溶劑添加法製備含有茶鹼的乙基纖維素微膠粒。並探討添加保護性膠體對微膠粒的性質影響。實驗結果顯示添加適量的保護性膠體可減少微膠粒聚集情形, 並使得微膠粒之表面較為緊密與平順。於保護性膠體的存在下, 利用乳化非溶劑添加法可製備單核(Mononucleated)的乙基纖維素微膠粒。因微膠粒的聚集現象, 茶鹼的釋放行為乃遵循基質中擴散控制模式, 其釋放速率的快慢則依微膠粒的聚集程度與孔隙度而定。
• 英文摘要： Preparation of ethylcellulose microcapsules containing theophylline was performed by simple non-solvent addition and emulsion non-solvent addition methods in the presence of polybutadiene or polyisobutylene as a protective colloid. The effects of the protective colloids upon the properties of microcapsules with respect to the size distribution, drug content, ethylcellulose loss and porosity were characterized. The results indicate that, in the presence of an appropriate amount of the protective colloid, the extent of aggregation was reduced and the surface became smoother and less porous. Mononucleated microcapsules were obtained by the emulsion non-solvent addition method in the presence of polyisobutylene. Owing to the occurrence of aggregation, the theophylline release from microcapsules appeared to follow the diffusion- controlled matrix model, the release rate being dependent upon the extent of aggregation and the porosity of microcapsules.
• 中文關鍵字： 微粒包覆; 乙基纖維素; 保護性膠體; 茶鹼; 非溶劑添加; 孔隙率
• 英文關鍵字： Microencapsulation; Ethylcellulose; Protective Colloid; Theophylline; Non Solvent Addition; Porosity