- 作者: 王西照,賈 炯,張 妍,徐為人,劉 崴,石方牛,王建武
- 作者服務機構: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China
- 中文摘要: The synthesis of a series of new 5-isoxazolpenicillins is described, which were obtained by coupling substituted isoxazoles with 6-APA. Concise large-scale synthesis of 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition using copper(I) as catalyst was also investigated. Representative compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-negative bacteria.
- 英文摘要: --
- 中文關鍵字: Penicillin; Isoxazole; Synthesis; Antimicrobial activity.
- 英文關鍵字: --