• 作者： 方深毅; 沈清良
• 作者服務機構： 國立成功大學醫學院 耳鼻喉學科 解剖學科
• 中文摘要： 　　神經胜對於鼻黏膜的免疫功能，腺體分必等生理作用具有重要的影響力。本實驗的目的就是要了解這些神經胜在人類鼻部疾病的病理生理學上扮演什麼角色，所以首要的就是證明它們的存在及了解其分布的特性和組織的濃度。我們選用20位過敏性鼻炎，25位慢性肥厚性鼻炎及10位正常者的下鼻甲黏膜以免疫組織化學染色法及利用放射免疫檢測法來檢查vasoactive intestinal peptides (VIP)，neuropeptide Y (NPY)，substance P (SP)，calcitonin gene-related peptide(CGRP)等神經胜。結果：VIP神經纖維在過敏性鼻炎集中於血管旁，而在肥厚性鼻炎集中於腺體旁。其它神經胜在第3組之間無明顯區別。組織濃度以VIP為最高，CGRP最低。VIP及SP在過敏性鼻炎具較高濃度。結論：VIP與慢性肥厚性鼻炎的形成可能有關，而VIP與SP在導致過敏性鼻炎的神經免疫學上扮演重要角色。
• 英文摘要： This study aims to investigate the roles of neuropeptides in the pathophysiology of human nasal dis-eases. By using immunohistochemistry and radioimmunoassay, we detected the presence, distribution andconcentrations of the following neuropeptides in human nasal tissue: vasoactive intestinal peptides (VIP),neuropeptide Y (NPY), substance P (SP), and calcitonin gene-related peptides (CGRP). This was per-formed in human nasal inferior turbinate mucosa from 20 patients with allergic rhinitis, twenty-five patientswith chronic hypertrophic rhinitis and 10 patients without any nasal disease conditions. The presence anddistribution of NPY, CGRP and SP fibers among the three subject groups displayed no evident differences.VIP fibers were densely stained around the vessels in the allergic group. In contrast, these fibers were moreprominantly distributed around the submucosal glands of the chronic hypertrophic rhinitis group. The con-centration of VIP and SP in human nasal inferior turbinate showed a significant increase in allergic sub-jects. Thus, VIP may be revelant to the hypertrophic changes of the nasal mucosa. Both SP and VIP mayplay significant neuroimmunological roles in the pathogenesis of allergic rhinitis.
• 中文關鍵字： neuropeptids; nasal mucosa; allergic rhinitis; chronic rhinitis.
• 英文關鍵字： --