- 作者: --
- 作者服務機構: Department of Chemistry, Bahauddin Zakariya University, Multan 60800, Pakistan
- 中文摘要: A simple, rapid, cost effective and extraction-free spectrophotometric method has been developed for the determination of zolmitriptan in pharmaceutical raw and dosage forms. The method is based on the charge-transfer reaction of zolmitriptan in acetonitrile medium with 0.2% 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form a colored product peaking at 555 nm. Beer’s law is obeyed in the concentration range 10-250 mg mL–1 with molar absorptivity of 1.7 ’ 103 L mole-1 cm-1. The effects of variables such as reagent concentration, time of reaction, color stability and interferences have been investigated to optimize the procedure. The results have been validated analytically and statistically. The proposed method has been successfully applied for the determination of zolmitriptan in pharmaceutical formulations. Results indicate that the method is accurate, precise and reproducible (relative standard deviation < 2%).
- 英文摘要: --
- 中文關鍵字: Spectrophotometric determination; Zolmitriptan; Pharmaceutical formulations
- 英文關鍵字: --