- 作者: Aadhya Tiwari, Rakesh Trivedi & Shiaw-Yih Lin
- 作者服務機構: 1.Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2.Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
- 中文摘要:
- 英文摘要:
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for success‑
ful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic methodologies,
it is now possible to study TME’s individual components and their interplay at higher resolution. Deeper understand‑
ing of the immune cell’s diversity, stromal constituents, repertoire profling, neoantigen prediction of TMEs has
provided the opportunity to explore the spatial and temporal regulation of immune therapeutic interventions. The
variation of TME composition among patients plays an important role in determining responders and non-responders
towards cancer immunotherapy. Therefore, there could be a possibility of reprogramming of TME components to
overcome the widely prevailing issue of immunotherapeutic resistance. The focus of the present review is to under‑
stand the complexity of TME and comprehending future perspective of its components as potential therapeutic
targets. The later part of the review describes the sophisticated 3D models emerging as valuable means to study TME
components and an extensive account of advanced bioinformatic tools to profle TME components and predict neo‑
antigens. Overall, this review provides a comprehensive account of the current knowledge available to target TME. - 中文關鍵字:
- 英文關鍵字: Tumor microenvironment, Cancer immunotherapy, 3D models, Checkpoint inhibitors, Specialized microenvironment, TME profling, CAR-T/NK therapy