- 作者: Subit Barua, Salomon Kuizon, Mohammed A Junaid
- 作者服務機構: Department of Developmental Biochemistry, New York State Institute for Basic Research in Developmental Disabilities, NY, USA
- 中文摘要: --
- 英文摘要: Maternal exposure to dietary factors during pregnancy can influence embryonic development and may modulate the phenotype of offspring through epigenetic programming. Folate is critical for nucleotide synthesis, and preconceptional intake of dietary folic acid (FA) is credited with reduced incidences of neural tube defects in infants. While fortification of grains with FA resulted in a positive public-health outcome, concern has been raised for the need for further investigation of unintended consequences and potential health hazards arising from excessive FA intakes, especially following reports that FA may exert epigenetic effects. The objective of this article is to discuss the role of FA in human health and to review the benefits, concerns and epigenetic effects of maternal FA on the basis of recent findings that are important to design future studies.
- 中文關鍵字: --
- 英文關鍵字: Folic acid; DNA methylation; Epigenetic; Imprinting; Prenatal nutrition; Neural tube defects; Autism