- 作者: Mokhtar,Hassan M. ; El-Khawass,S.M.
- 作者服務機構: Chemistry Department, Alexandria University, Egypt
- 中文摘要: A novel series of 1,3,5-trisubstituted pyrazoles was synthesized. Thus, ethyl 2,4-dioxo-6-phenylhex- 5-enoate (I) was condensed with phenylhydrazine to afford 3- ethoxycarbonyl-1-phenyl-5-styrylpyrazole (II) which on fusion with hydrazine hydrate gave the corresponding acid hydrazide (III). Reaction of III with the appropriate isothiocyanate yielded the disubstituted thiosemicarbazides(IVa-e) which were cyclized into thiotriazoles (Va-e), thiadiazoles (VIa-e) and oxadiazoles (VIIa-). The structure of the newly synthesized compounds was elucidated by elemental analyses, IR and /sup 1/H NMR spectra.
- 英文摘要: --
- 中文關鍵字: Hypoglycemic Agent; Pyrazole; Synthesis
- 英文關鍵字: 降血糖劑;唑;合成