- 作者: Junjun Quan, Zhongli Jia, Tiewei Lv, Lei Zhang, Lingjuan Liu, Bo Pan, Jing Zhu, Ira J. Gelb, Xupei Huang and Jie Tian
- 作者服務機構: 1. Department of Cardiology, Children’s Hospital of Chongqing Medical University, 136 Zhongshan Er Road, Yu Zhong District, Chongqing, 400014, China 2. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China 3. China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China 4. Chongqing Key Laboratory of Pediatrics, Chongqing, China
- 中文摘要:
- 英文摘要:
Background
Our previous studies have demonstrated that Ca2+ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effects of green tea extract catechin on cardiac function and other clinical features in pediatric patients with cardiomyopathies.
Methods
Twelve pediatric cardiomyopathy patients with diastolic dysfunction were enrolled for the study. Echocardiography, ECG, and laboratory tests were performed before and after the catechin administration for 12 months. Comparison has been made in these patients before and after the treatment with catechin. Next Generation Sequencing was conducted to find out the potential causative gene variants in all patients.
Results
A significant decrease of isovolumetric relaxation time (115 ± 46 vs 100 ± 42 ms, P = 0.047 at 6 months; 115 ± 46 vs 94 ± 30 ms, P = 0.033 at 12 months), an increase of left ventricle end diastolic volume (40 ± 28 vs 53 ± 28 ml, P = 0.028 at 6 months; 40 ± 28 vs 48 ± 33 ml, P = 0.011 at 12 months) and stroke volume (25 ± 16 vs 32 ± 17 ml, P = 0.022 at 6 months; 25 ± 16 vs 30 ± 17 ml, P = 0.021 at 12 months) were observed with echocardiography in these patients 6-month after the treatment with catechin. Ejection fraction, left ventricular wall thickness, biatrial dimension remained unchanged. No significant side effects were observed in the patients tested.
Conclusions
This study indicates that Ca2+ desensitizing green tea extract catechin, is helpful in correcting the impaired relaxation in pediatric cardiomyopathy patients with diastolic dysfunction. - 中文關鍵字:
- 英文關鍵字: Hypertrophic cardiomyopathy, Restrictive cardiomyopathy, Diastolic dysfunction, Green tea extract catechin