- 作者: Kai-Wei Lin, Shu-Ching Chen, Fu-Hsiung Chang John T, Kung, Brend Ray-Sea Hsu, Rong-Hwa Lin
- 作者服務機構: Graduate Institutes of "Immunology and Biochemistry, College of Medicine, National Taiwan University, Institute of Molecular Biology, Academia Sinica ,Taipei ,Division of Endocrinology and Metabolism Chang-Gung Memorial Hospital, Lin-Kou Medical Center ,Taoyuan, "AbGenomics Corporation, Taipei, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Despite evidence that interleukin (IL)-1 promotes the pro-liferation of some T helper 2 (Th2) cell clones in vitro, thephysiological role of IL-1 in the regulation of antigen-spe-cific immune responses remains undefined. Using a lipo-some-DNA delivery system, we transiently expressedIL-1 receptor antagonist (IL-1 Ra) to suppress IL-1 func-tions at the site of the antigen-specific primary immuneresponse. Our data indicate, for the first time, that IL-1 Radownregulates antigen-specific IL-4 and IgE responses,with concomitant enhancement of interferon- andIgG2a responses in vivo. In addition, IL-1 can promoteTh2 development in an IL-4-independent manner in vi-tro. Thus, the balance between endogenous IL-1 and IL-1Ra during the primary immune response can be animportant factor in determining the antigen-specific ef-fector function of T cells.
- 中文關鍵字: --
- 英文關鍵字: Interleukin-1 receptor antagonist, Interleukin-1, Immune response, T cell