- 作者: 莊大賢,吳培琳
- 作者服務機構: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, R.O.C.
- 中文摘要: A series of isoquinolinones have been synthesized by one-pot Curtius rearrangement and cyclization of the corresponding cinnamoyl azides using Hg(OAc)2 as the catalyst under refluxing o-dichlorobenzene. This is the first time that the intermediate carbamoylisoquinolinone 4 in the synthesis of isoquinolinones has been reported. The nature of the substituent on the aromatic ring was found to be crucial to obtaining high yields of isoquinolinone. The mechanism of the reaction was also discussed.
- 英文摘要: --
- 中文關鍵字: Isoquinolinone; Cinnamoyl azide; Isocyanate; Curtius rearrangement; Cyclization.
- 英文關鍵字: --