• 作者： 賴陳欽; 林仁混
• 作者服務機構： 國立臺灣大學醫學院生化學科; 行政院國科會癌症研究推動小組癌症預防工作組
• 中文摘要： 關於硝酸鹽還原?的上二次報告已提出一些乳酸菌製劑含有硝酸鹽還原?之活性，因此，對
  該等製劑在腸胃中增加亞硝酸鹽（可與二級胺或三級胺反應而形成致癌性的亞硝胺）的可能性，
  認為有進一步做動物實驗的必要。
  本研究由老鼠實驗結果顯示，經乳酸菌製劑投與的動物，再加給予硝酸鹽，可提高胃中的亞
  硝酸鹽濃度達兩倍以上。更有趣的是，若硝酸鹽與碳酸氫鈉同時投予，更能增加亞硝酸鹽的濃度
  （四倍以上）。
  由更進一步的實驗，獲知二級胺與硝酸鹽同時給予動物，其毒力不顯，但若再加乳酸菌製劑
  則其毒力大大增加。
  本研究結果有二個啟示：(1)關於胃病患者使用乳酸菌製劑時，制酸劑 (antacid) 如碳酸氫鈉
  是否可能構成配伍禁忌需待更進一步的探討。(2)食物中之硝酸鹽對體內亞硝酸，甚至亞硝胺的產
  生可能擔當著積極的角色。
• 英文摘要： In the previous studies, we have demons-trated that most gastrointestinal flora containnitrate reductase and most commercial Lactoba-cillus preparations also possess this enzymeactivity. These findings prompted us to in-vestigate the effects of Lactobacillus preparationson the concentration of gastrointestinal nitritein rats. Lactobacillus preparation was found tochange the distribution of nitrite in the gastro-intestinal tracts of rats. It is worthy to notethat the concentration of nitrite in the stomachwas elevated by Lactobacillus treatment; theelevation was enhanced by concomitant adminis-tration of sodium bicarbonate (as antacid). Lactobacillus preparation was also foundto increase the toxicity of some secondary am-ines when they were administered with sodiumnirtate. These experimental results provide twoimplications: First, Lactobacillus preparationsmay pose the problem of incompatibility toantacids prescribed to the patients with gas-trointestinal disturbances; Second, dietary nitratemay play important role in the formation ofnitrite and carcinogenic nitrosamines in vivo.
• 中文關鍵字： --
• 英文關鍵字： --