- 作者: 袁尚賢 ; Ajami, Alfred M.
- 作者服務機構: Tracer Technologies, Inc., Somerville, Massachusetts, U.S.A.
- 中文摘要: Cobalt catalyzed hydroformylation-amidocarbonylation of 3-cyanopropene by carbon-13 monoxide and acetamide produced a (1,2-/sup 13/C/sub 2/)-labelled mixture of 5-cyano-2-acetamidopentanoic acid and 4-cyano-3-methyl-2-acetamidobutanoic acid (n to b ratio of 7 to 3, 55% yield). Acylase I resolution of this mixture gave the free S-amino acids which could be separated by crystallization. Catalytic reduction of the cyano group of the straight chain acid furnished(1,2-/sup 13/C/sub 2/)-S-lysine- HCl.
- 英文摘要: --
- 中文關鍵字: Cobalt Acetate; 3-Cyanopropene; Carbon-13 Monoxide; Hydroformylation; Amidocarbonylation; (1,2-/Sup 13/C/Sub 2/)-S-Lysine; Stable Isotopes; Label
- 英文關鍵字: 醋酸鈷;3-氰基丙烯;一氧化碳13;加氫醛化;醯胺羰基化作用;1;2-二碳13-硫-2;6-二氨基己酸;穩定同位素;標幟