• 作者： 王進崑; 孫璐西
• 作者服務機構： 中山醫學院營養科學研究所; 臺灣大學食品科技研究所
• 中文摘要： 在臺灣，嚼食檳榔已被發現對健康及環境造成很大的影響。許多人喜歡嚼食檳榔是因為檳榔嚼食後之提神及興奮感覺。本研究利用牛之腎上腺髓質細胞及官能品評，探討嚼食檳榔之生理反應及檳榔嚼塊中各種配料（檳榔果實、荖花及紅灰）間之反應。完整之檳榔嚼塊（檳榔果實、荖花及紅灰）與檳榔果實及紅灰之混合物在咀嚼時有心跳加速、微醉、發汗及增加唾液分泌等反應，而這兩者皆可較單一配料或其他之混合配料誘發嗜鉻細胞分泌更多的腎上腺素。結果顯示，以嗜鉻鈿胞分泌腎上腺素之交感神經模式系統與人的實際生理反應問有很好的相關性。而檳榔嚼塊對於carbachol與高鉀溶液所誘發之腎上腺素分泌皆具抑制效果，此表示檳榔嚼塊會誘發嗜鉻細胞分泌腎上腺素之作用，可能是發生在細胞發生去極化作用後鈣離子進入細胞之後的步驟上所引起的。
• 英文摘要： Health damage and environmental pollution are serious problems caused by betel quid chewing inTaiwan. Many people acquire the habit of chewing betel quid due to its physiological effects, including in-creased stamina and a general feeling of well-being. In this study, a sympathetic model system of adrenalchromaffin cells and sensory evaluation were used to examine the physiological effects of betel quid and theinteraction of all the ingredients (areca fruit, Piper betle inflorescence and red lime paste) in betel quid.Physiological effects of cardioacceleration, a slightly drunk feeling, sweating and salivation occurred duringthe chewing of betel quid (a mixture of areca fruit, Piper betle inflorescence and red lime paste) and a mixtureof areca fruit and red lime paste. Both induced much more basal catecholamine secretion from adrenal chro-maffin cells than did other ingredients and combinations of ingredients. It was evident that the responses inthe sympathetic model system were closely correlated with the physiological feeling of well-being. Theinhibitory effects of all the chewing juices on catecholamine secretion evoked by carbachol and a highconcentration of potassium (high K+) showed that they perhaps affected the calcium influx throughvoltage-sensitive channels or the steps involved in secretion after calcium entry to stimulate basal catechol-amine secretion from chromaffin cells.
• 中文關鍵字： betel quid; adrenal chromaffin cells; catecholamin secretion.
• 英文關鍵字： --