- 作者: Najmeh Rahmanian, Seyed Jalal Hosseinimehr and Ali Khalaj
- 作者服務機構: 1. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran 2. Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
- 中文摘要: --
- 英文摘要:
Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resulted in apoptosis in cancer cells, it also stimulates tumor cell re-population that leads to reduce the effectiveness of the radiation therapy. This review describes the mechanisms for paradox role of caspase cascade in cancer therapy and discusses the logical and practical strategies for improvement the therapeutic index of radiotherapy through enhancement of radiosensitivity and decreasing the rate of tumor recurrence. - 中文關鍵字: --
- 英文關鍵字: Caspase, Radiotherapy, Cancer, Treatment, Induction