- 作者: 李衛東 ; 李裕林 ; 李瀛
- 作者服務機構: 天津巿南開大學元素有機化學研究所
- 中文摘要: A chiral precursor of sarcophytol-Q, (11S)-3,7,11,15- tetramethyl-11-hydroxy-14-oxo-3E,7E,12E-hexadecatrienal, was synthesized in a convergent and stereoselective manner starting from geraniol and 4-hydroxy-2-butanone in mine steps. The key steps were asymmetric Sharpless epoxidation, base-induced dehydrohalogenation rearrangement of chiral epoxy chloride and the phase transfer catalytic coupling reaction of allylic phenyl sulfone with chiral allylic chloride.
- 英文摘要: --
- 中文關鍵字: Macrocyclic Diterpenoid; Precursor; Synthesis; Stereoselective Synthesis; Sarcophytol-Q
- 英文關鍵字: 巨環化雙類;前驅體;合成;立體選擇性合成