- 作者: 翁啟惠
- 作者服務機構: Deoartment of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Intitute
- 中文摘要: Carbohydrates have been known as poor candidates for drug development. Recent studies have, however, shown that structurally simplified small molecules as mimics of complex carbohydrates recognized by receptors can be developed as inhibitors of carbohydrate-mediated biological recognition. In addition, small molecules with higher affinity and specificity than the parent ligands can be developed by incorporating additional hydrophobic or charged groups in the carbohydrate mimetic which contains essential functional groups for receptor binding. Representative examples are illustrated in the studies of sialyl Lewis x-selection interactions, glycosidase and glycosyltransferase reactions and aminoglycoside antibiotic - RNA interactions .
- 英文摘要: --
- 中文關鍵字: Carbohydrate Mimetics; Glycosyltransfer Enzyme; Aminoglycoside Antibiotic; Carbohydrate Analoque; Carbohydrate Diated Biological Recognition
- 英文關鍵字: 擬醣類結構;葡萄糖傳遞酵素;氨醣類抗生素;醣類類似物;糖類仲介生物辨識