- 作者： 彭明聰; 楊志良; 楊維哲
- 作者服務機構： 國立臺灣大學 醫學院生理學科 公共衛生學科 理學院數學系
- 中文摘要：
在12小時照光、12小時黑暗(LD)及24小時連續照光(LL)情況下連續記錄年老雄鼠22個月以上之活動，攝食及飲水
行為並與年輕雄鼠3.5至6.5個月比較，以利探討此等行為日夜間律動之中樞性機構在年老時有何機能上改變。
在LD情況12小時黑暗中年輕鼠及年老鼠之活動，攝食及飲水行為均有二至三個高?，在12小時照光中年輕鼠此三
種行為並無高?，但8隻年老鼠2隻在活動，10隻年老鼠中6隻在攝食，6隻年老鼠中1隻在飲食行為有一至二個中等
或高?，以致此三種行為之日夜間差別消失。
在LD 情況，年老鼠活動的水準，24小時週期之幅度，比24小時短的週期之幅度，一日活動量，一日中連續出現的
一連活動次數及其平均期間，日夜間差別消失之6隻年老鼠之攝食之水準，24小時週期之幅度，比24小時短的週期之幅
度及一日中餐次及連續出現的一連的飲水行為的平均期間比年輕鼠小或短。
但尚有日夜間差別的4隻年老鼠之攝食水準，24小時週期之幅度，比24小時短的週期之幅度及飲水之水準比年輕鼠
高。
LL 抑制年輕鼠的一日活動量，一日攝食次數，一日飲水次數，活動及飲水之水準及24小時週期的幅度，飲水行為
之比24小時短的週期的幅度，一日中連續出現的一連的活動次數，一日餐次，一日中連續出現的一連的飲水次數及其期
間，但在年老鼠只抑制飲水行為的水準，一日中飲水次數，尚有日夜間差別年老鼠之一日攝食次數及年老鼠每餐期間及
餐間間隔。
年老鼠各種行為對 LL 之抑制反應降低之各種原因及可能性最後提出討論。
h - 英文摘要： Circadian rhythms of running-wheel activity, food intake and drinking were monitored in old malerats of Long-Evans strain over 22 months of age in both entrained (light:dark 12：12, LD) and free runningcondition (continuous illumination, LL) and were compared with those of young adult male rats of 3.5 to6.5 months of age. Twenty-four hour distribution of running activity, feeding events and licking events ofyoung rats as well as old rats showed bi- or tri-modal patterns during the 12 hr dark period of the LDschedule. In the light period, 2 out of 8 old rats, 6 out of 10 old rats and 1 out of 6 old rats had 1 or 2medium or high peaks in running activity, feeding events and licking events, respectively, leading to equaldistribution between the dark and light period. In the LD schedule, old rats showed a decrease in running-wheel activity, its patterns and power spectra, a decrease in feeding events and its power spectra in 6rats which lost circadian rhythms and increase in feeding events and its power spectra in 4 rats which stillshowed circadian rhythms and increase in licking events. LL suppressed running-wheel activity, its patternsand power spectra, licking events and its power spectra and feeding events in young rats. However, LLcould suppress only feeding events of 4 rats which still showed circadian rhythms and licking events and itsspectral level in old rats. The possible causes of decreased response to LL in old rats and its implication arediscussed.
- 中文關鍵字： circadina peak; drinking; feeding; old male rats; power spectrum; running-wheel activity; ultradina peak
- 英文關鍵字： --
