- 作者: Anushka Deshpande, Prithviraj Manohar Vijaya Shetty, Norbert Frey & Ashraf Yusuf Rangrez
- 作者服務機構: 1.Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, Germany 2.Department of Internal Medicine III, Cardiology and Angiology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany 3.DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/Lübeck, Kiel, Germany 4.DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
- 中文摘要:
- 英文摘要:
The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal
transduction pathways within or between diferent cell lineages via autocrine or paracrine mechanisms of action.
The heart is the frst functional organ to form during development, which highlights the importance of this organ in
later stages of growth. Knowledge of the regulatory mechanisms underlying cardiac development and adult cardiac
homeostasis paves the way for discovering therapeutic possibilities for cardiac disease treatment. Serum response factor (SRF) is a major transcription factor that controls both embryonic and adult cardiac development. SRF expression is
needed through the duration of development, from the frst mesodermal cell in a developing embryo to the last cell
damaged by infarction in the myocardium. Precise regulation of SRF expression is critical for mesoderm formation and
cardiac crescent formation in the embryo, and altered SRF levels lead to cardiomyopathies in the adult heart, suggesting the vital role played by SRF in cardiac development and disease. This review provides a detailed overview of SRF
and its partners in their various functions and discusses the future scope and possible therapeutic potential of SRF in
the cardiovascular system. - 中文關鍵字:
- 英文關鍵字: COVID-19, Monoclonal antibody, Neutralization, SARS-CoV-2, Variant