- 作者: Yi-Ling Chen Chung-Keung Yu Huan-Yao Lei
- 作者服務機構: Department of Microbiology and Immunology, College of Medicine, National cheng Kung University. Taipei, Taiwan, ROC
- 中文摘要: --
- 英文摘要: The CD3+/TCRαβ+ T-cell-mediated hepatic inflammationinduced by Propionibacterium acnes could be dividedinto an acute and a chronic phase. The acute phaseoccurred within 72 h after injection and displayed hepat-ic apoptosis. Anti-TNFa antibody inhibited both theP. acnes-induced hepatic apoptosis and lymphocyte infil-tration seen in this phase, indicating the involvement ofthis cytokine. Thereafter, a chronic phase was mani-fested from days 7 to 14 after injection. It was character-ized as granulomatous inflammation admixed withapoptosis of infiltrating lymphocytes and some hepato-cytes. Immunohistochemical staining showed that theinfiltrating lymphocytes displayed TNFα, TNF type I re-ceptor and a variety of cytokines including IL-1β, IL-4,IL-6, IL-10, IFNγ or IL-12. Interestingly, in naive mice, thearteries in the liver constitutively expressed IFNγ. Itsexpression appeared to be substantially increased at48 h, decreased at 72 h, and increased again on day 14after P. acnes injection. Furthermore, Fas or Fast wasonly detected on the lymphocytes within the granuloma.We conclude that P. acnes can induce a TNFα-mediatedacute hepatic apoptosis which subsequently progress toa T-cell-mediated granulomatous hepatitis with in-creased expression of multiple cytokines and Fas/FasL.
- 中文關鍵字: --
- 英文關鍵字: TNFa. Fas. FasL. Apoptosis. Cytokine